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You’ll be in good company. In addition, cultured keratinocytes infected with a recombinant adenovirus expressing DLK exhibited morphological and biochemical changes, including a suprabasal localization, altered cell shape, compacted cytoplasm, DNA fragmentation, and the up-regulation of filaggrin, that are reminiscent of a terminally differentiated phenotype. Services Email this article to a friend Alert me when this article is cited Alert me if a correction is posted Alert me when eletters are published Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Download to citation manager Request Permissions. Search for related content. This Article First Published on January 28, doi: Classifications Mechanisms of Signal Transduction.

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This Article First Published on January 28, doi: In support of this notion, we showed that DLK expression was restricted to the granular layer in situ.

Articles by Germain, L. Journal of Lipid Research.

Abstract In the skin, epithelial cells undergo a terminal differentiation program leading to the formation of the stratum corneum.

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We now report dllk a single kinase, the mitogen-activated protein kinase kinase kinase dual leucine zipper-bearing kinase DLKacts in the epidermis to promote the terminal differentiation of human keratinocytes. Classifications Mechanisms of Signal Transduction. Prev Next Table of Contents. Google Scholar Articles by Robitaille, H.

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In the skin, epithelial cells undergo a terminal differentiation dlj leading to the formation of the stratum corneum. To whom correspondence may be addressed: Moreover the expression of wild-type DLK in keratinocytes stimulated transglutaminase activity and the consequent formation of the cornified cell envelope, while a kinase-inactive variant of DLK did not.

View this article with LENS. Together these results identify DLK as a signaling molecule implicated in the regulation of keratinocyte terminal differentiation and cornification.

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Search for related content. Related Content Load related web page information. In addition, cultured keratinocytes infected with a recombinant adenovirus expressing DLK exhibited morphological and biochemical changes, including a suprabasal localization, altered cell shape, compacted cytoplasm, DNA fragmentation, and the up-regulation of filaggrin, that are reminiscent of a terminally differentiated phenotype.

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Services Email this article to a friend Alert me when this article is cited Alert me if a correction is posted Alert me when eletters are published Similar articles vlk this journal Vlk articles in Web of Science Similar articles in PubMed Download to citation manager Request Permissions. You’ll be in good company. Although it is expected that the last phases of this process must be tightly regulated since it results in cell death, the signaling pathways involved in this induction remain ill defined.